منابع مشابه
MULTIPLE MYELOMA Myeloma bone disease
Bone destruction is a hallmark of multiple myeloma, and recent studies demonstrated a strong interdependence between tumor progression and bone resorption. Increased bone resorption as a major characteristic of multiple myeloma is caused by osteoclast activation and osteoblast inhibition (uncoupling). Myeloma cells alter the local regulation of bone metabolism by increasing the receptor activat...
متن کاملMyeloma Bone Disease
Found in >80% of newly diagnosed patients, osteolytic bone disease is one of the most debilitating manifestations of myeloma. It dramatically impacts patient quality of life through severe pain, fractures, and spinal cord compression, with resulting neurological pathologies. The severity of myeloma bone disease is reflected in the fact that 40–60% of patients suffer from a bone fracture during ...
متن کاملTreatment for myeloma bone disease.
Multiple myeloma (MM) is a B cell malignancy characterized by enhanced bone loss commonly associated with diffuse osteopenia, focal lytic lesions, pathologic fractures, hypercalcemia, and bony pain. Bone destruction in MM results from asynchronous bone turnover wherein increased osteoclastic bone resorption is not accompanied by a comparable increase in bone formation. Consequently, patients wi...
متن کاملBone disease in multiple myeloma.
Multiple myeloma is a uniformly fatal hematologic malignancy that results from the clonal expansion of plasma cells within the bone marrow. Skeletal-related complications affect nearly all patients with multiple myeloma and have a major impact on both patient morbidity and mortality. These complications most frequently include the development of osteolytic lesions that lead to severe bone pain,...
متن کاملBone Disease in Multiple Myeloma
Osteolytic bone disease in multiple myeloma (MM) is a common event. Already at diagnosis, approximately eighty percent of patients present with abnormal bone structure [1;2]. During disease progression a large proportion of patients will develop ostelytic lesions [3]. MM bone disease not only results in a reduced quality of life due to pain, pathological fractures, or symptomatic hypercalcaemia...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2009
ISSN: 0884-0431,0884-0431
DOI: 10.1359/jbmr.090901